Prostate Radiotherapy for Metastatic Hormone-sensitive Prostate Cancer: A STOPCAP Systematic Review and Meta-analysis.

ABSTRACT:

Background

Many trials are evaluating therapies for men with metastatic hormone-sensitive prostate cancer (mHSPC).

Objective

To systematically review trials of prostate radiotherapy.

Design, setting, and participants

Using a prospective framework (framework for adaptive meta-analysis [FAME]), we prespecified methods before any trial results were known. We searched extensively for eligible trials and asked investigators when results would be available. We could then anticipate that a definitive meta-analysis of the effects of prostate radiotherapy was possible. We obtained prepublication, unpublished, and harmonised results from investigators.

Intervention

We included trials that randomised men to prostate radiotherapy and androgen deprivation therapy (ADT) or A

SUBMITTER: Burdett S 

PROVIDER: S-EPMC6575150 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature