Caspase-8 promotes c-Rel-dependent inflammatory cytokine expression and resistance against <i>Toxoplasma gondii</i>.

ABSTRACT: Caspase-8 is a key integrator of cell survival and cell death decisions during infection and inflammation. Following engagement of tumor necrosis factor superfamily receptors or certain Toll-like receptors (TLRs), caspase-8 initiates cell-extrinsic apoptosis while inhibiting RIPK3-dependent programmed necrosis. In addition, caspase-8 has an important, albeit less well understood, role in cell-intrinsic inflammatory gene expression. Macrophages lacking caspase-8 or the adaptor FADD have defective inflammatory cytokine expression and inflammasome priming in response to bacterial infection or TLR stimulation. How caspase-8 regulates cytokine gene expression, and whether caspase-8-mediated gene regulation has a physiological role during infection, remain poorly defined. Here we demonstrate tha

SUBMITTER: DeLaney AA 

PROVIDER: S-EPMC6575527 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature