An activatable PET imaging radioprobe is a dynamic reporter of myeloperoxidase activity in vivo.

ABSTRACT: Myeloperoxidase (MPO) is a critical proinflammatory enzyme implicated in cardiovascular, neurological, and rheumatological diseases. Emerging therapies targeting inflammation have raised interest in tracking MPO activity in patients. We describe ¹⁸F-MAPP, an activatable MPO activity radioprobe for positron emission tomography (PET) imaging. The activated radioprobe binds to proteins and accumulates at sites of MPO activity. The radioprobe ¹⁸F-MAPP has a short blood half-life, remains stable in plasma, does not demonstrate cytotoxicity, and crosses the intact blood-brain barrier. The ¹⁸F-MAPP imaging detected sites of elevated MPO activity in living mice embedded with human MPO and in mice induced with chemical inflammation or myocardial infarction. The

SUBMITTER: Wang C 

PROVIDER: S-EPMC6575581 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature