Adverse organogenesis and predisposed long-term metabolic syndrome from prenatal exposure to fine particulate matter.

ABSTRACT: Exposure to fine particulate matter (PM) during pregnancy is associated with high risks of birth defects/fatality and adverse long-term postnatal health. However, limited mechanistic data are available to assess the detailed impacts of prenatal PM exposure. Here we evaluate fine PM exposure during pregnancy on prenatal/postnatal organogenesis in offspring and in predisposing metabolic syndrome for adult life. Between days 0 and 18 of gestation, two groups of adult female rats (n = 10 for each) were placed in a dual-exposure chamber device, one with clean ambient air (∼3 µg·m^-3) and the other with ambient air in the presence of 100 to 200 µg·m^-3 of ultrafine aerosols of ammonium sulfate. At birth (postnatal day 0, PND0), four males and four females were selected

SUBMITTER: Wu G 

PROVIDER: S-EPMC6575589 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature