Ontology highlight
ABSTRACT:
SUBMITTER: Kotzin JJ
PROVIDER: S-EPMC6575676 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20190528 24
The transcriptional programs that regulate CD8 T-cell differentiation and function in the context of viral infections or tumor immune surveillance have been extensively studied; yet how long noncoding RNAs (lncRNAs) and the loci that transcribe them contribute to the regulation of CD8 T cells during viral infections remains largely unexplored. Here, we report that transcription of the lncRNA <i>Morrbid</i> is specifically induced by T-cell receptor (TCR) and type I IFN stimulation during the ear ...[more]