CACNA1C (rs1006737) may be a susceptibility gene for schizophrenia: An updated meta-analysis.

ABSTRACT:

Introduction

Schizophrenia is a serious mental illness with a genetic predisposition. Genome-wide association studies (GWAS) have identified the α-1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene as a significant risk gene for schizophrenia. However, there are inconsistent conclusions in case-control studies.

Methods

We performed a comprehensive meta-analysis of all available samples from existing studies under four different genetic models (recessive model, dominant model, additive model and allele model) to further confirm whether CACNA1C rs1006737 is an authentic risk single nucleotide polymorphism (SNP) for schizophrenia.

Results

A statistically significant difference under the four models (all p < 0.05) was observed by pooling nine Asian and

SUBMITTER: Zhu D 

PROVIDER: S-EPMC6576147 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature