Astrocyte growth, reactivity, and the target of the antiproliferative antibody, TAPA.

ABSTRACT: Reactive astrocytes form a scar after injury to the CNS that many investigators believe contributes to the lack of functional regeneration. In the present study, we identify an astrocytic membrane protein that appears to play an important role in reactive gliosis and scar formation. Cultures of rat astrocytes were used as a model system to produce and to screen monoclonal antibodies that would alter cell growth. One antibody, AMP1, was identified that depresses the mitotic activity of cultured glial cells and alters their morphology. Expression cloning reveals that the antigen on the external surface of the cultured glial cells has a high degree of homology with the human lymphocyte protein called Target of the Anti-Proliferative Antibody (TAPA-1; this rat protein will be referred to as rT

SUBMITTER: Geisert EE 

PROVIDER: S-EPMC6578894 | biostudies-literature | 1996 Sep

REPOSITORIES: biostudies-literature