Coordinated expression of dopamine receptors in neostriatal medium spiny neurons.

ABSTRACT: In recent years, the distribution of dopamine receptor subtypes among the principal neurons of the neostriatum has been the subject of debate. Conventional anatomical and physiological approaches have yielded starkly different estimates of the extent to which D1 and D2 class dopamine receptors are colocalized. One plausible explanation for the discrepancy is that some dopamine receptors are present in physiologically significant numbers, but the mRNA for these receptors is not detectable with conventional techniques. To test this hypothesis, we examined the expression of DA receptors in individual neostriatal neurons by patch-clamp and RT-PCR techniques. Because of the strong correlation between peptide expression and projection site, medium spiny neurons were divided into three groups on

SUBMITTER: Surmeier DJ 

PROVIDER: S-EPMC6578920 | biostudies-literature | 1996 Oct

REPOSITORIES: biostudies-literature