Solid Organ Transplantation in HIV-Infected Recipients: History, Progress, and Frontiers.

ABSTRACT:

Purpose of review

End-stage organ disease prevalence is increasing among HIV-infected (HIV+) individuals. Trial and registry data confirm that solid organ transplantation (SOT) is efficacious in this population. Optimizing access to transplant and decreasing complications represent active frontiers.

Recent findings

HIV+ recipients historically experienced 2-4-fold higher rejection. Integrase strand transferase inhibitors (INSTIs) minimize drug interactions and may reduce rejection along with lymphodepleting induction immunosuppression. Hepatitis C virus (HCV) coinfection has been associated with inferior outcomes, yet direct-acting antivirals (DAAs) may mitigate this. Experience in South Africa and the US HIV Organ Policy Equity (HOPE) Act support HIV+ donor to HIV+ recipien

SUBMITTER: Werbel WA 

PROVIDER: S-EPMC6579039 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature