Systemic miRNA delivery by nontoxic nanoscale coordination polymers limits epithelial-to-mesenchymal transition and suppresses liver metastases of colorectal cancer.

ABSTRACT: Though early detection and treatment of primary tumors has significantly improved in recent years, metastatic disease remains among the most significant challenges in cancer therapy. Cancer cells can disseminate before the primary tumor is detected to form micro or gross metastases, requiring toxic systemic therapies. To prevent and suppress metastases, we have developed a nontoxic, long-circulating nanoscale coordination polymer (NCP) protecting microRNA (miRNA) in circulation and releasing it in tumors. Pt^IV(en)₂ [en = ethylenediamine] containing NCPs (PtEN) can release a nontoxic, kinetically inert Pt^II(en)₂ compound and carbon dioxide which aids the endosomal escape of its miRNA cargo, miR-655-3p. Without the presence of the PtEN core, the mi

SUBMITTER: Chan C 

PROVIDER: S-EPMC6579118 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature