Thyroid hormone-responsive genes in developing cerebellum include a novel synaptotagmin and a hairless homolog.

ABSTRACT: Proper development of the mammalian CNS requires sufficient thyroid hormone; thyroid hormone deficiency during a brief perinatal period produces severe neurological defects in humans and experimental animals. Thyroid hormone exerts its effects through nuclear receptors, which modulate the transcription of downstream genes in response to hormone binding. Surprisingly, few genes that are regulated by thyroid hormone receptors in the CNS have been described. Here, I report the isolation and characterization of genes that are expressed in response to thyroid hormone in developing rat brain. One such gene (Srg1) encodes a novel protein related to synaptotagmin, a protein involved in regulating neurotransmitter release; another (hr) encodes a putative zinc finger protein related to the product o

SUBMITTER: Thompson CC 

PROVIDER: S-EPMC6579223 | biostudies-literature | 1996 Dec

REPOSITORIES: biostudies-literature