Ontology highlight
ABSTRACT:
SUBMITTER: Posner R
PROVIDER: S-EPMC6579485 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Cell 20190606 7
It is unknown whether the activity of the nervous system can be inherited. In Caenorhabditis elegans nematodes, parental responses can transmit heritable small RNAs that regulate gene expression transgenerationally. In this study, we show that a neuronal process can impact the next generations. Neurons-specific synthesis of RDE-4-dependent small RNAs regulates germline amplified endogenous small interfering RNAs (siRNAs) and germline gene expression for multiple generations. Further, the product ...[more]