Parkinson's disease age at onset genome-wide association study: Defining heritability, genetic loci, and α-synuclein mechanisms.

ABSTRACT:

Background

Increasing evidence supports an extensive and complex genetic contribution to PD. Previous genome-wide association studies (GWAS) have shed light on the genetic basis of risk for this disease. However, the genetic determinants of PD age at onset are largely unknown.

Objectives

To identify the genetic determinants of PD age at onset.

Methods

Using genetic data of 28,568 PD cases, we performed a genome-wide association study based on PD age at onset.

Results

We estimated that the heritability of PD age at onset attributed to common genetic variation was ∼0.11, lower than the overall heritability of risk for PD (∼0.27), likely, in part, because of the subjective nature of this measure. We found two genome-wide significant association signals, one at SNC

SUBMITTER: Blauwendraat C 

PROVIDER: S-EPMC6579628 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature