Histamine-Receptor Antagonists Slow 10-km Cycling Performance in Competitive Cyclists.

ABSTRACT: Histamine is released within skeletal muscle during exercise. In humans, antihistamines have no effect on speed, power output, or time-to-completion of short-duration high-intensity exercise. In mice, blocking histamine's actions decreases speed and duration of endurance tasks. It is unknown if these opposing outcomes are the result of differences in histamine's actions between species or are related to duration and/or intensity of exercise, as blocking histamine during endurance exercise has not been examined in humans.

Purpose

Determine the effects of histamine-receptor antagonism on cycling time trial performance in humans, with and without a preceding bout of sustained steady-state exercise.

Methods

Eleven (3F) competitive cyclists performed six 10-km time trials on separ

SUBMITTER: Ely MR 

PROVIDER: S-EPMC6579648 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature