Impairment of cognitive flexibility in type 2 diabetic db/db mice.

ABSTRACT: Impaired executive function is a major peril for patients with type 2 diabetes, reducing quality of life and ability for diabetes management. Despite the significance of this impairment, few animal models of type 2 diabetes examine domains of executive function such as cognitive flexibility or working memory. Here, we evaluated these executive function domains in db/db mice, an established model of type 2 diabetes, at 10 and 24 weeks of age. The db/db mice showed impaired cognitive flexibility in the Morris water maze reversal phase. However, the db/db mice did not show apparent working memory disturbance in the spatial working memory version of the Morris water maze or in the radial water maze. We also examined axon initial segments (AIS) and nodes of Ranvier, key axonal domains for actio

SUBMITTER: Yermakov LM 

PROVIDER: S-EPMC6579681 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature