Reduced mortality from lower respiratory tract disease in adult diabetic patients treated with metformin.

ABSTRACT:

Background and objective

Chronic lower respiratory diseases (CLRD) increase the risk of type 2 diabetes, which in turn may worsen lung function. Metformin, a common antidiabetic with anti-inflammatory and antioxidant properties, may improve respiratory outcomes. Therefore, we examined the association of metformin use with the risk of mortality from CLRD.

Methods

We analysed data from the National Health and Nutrition Examination Survey during 1988-1994 and 1999-2010 for participants aged 40 years or older who had diabetes and were followed up for mortality through 2011. Information on prescription medicine was collected at baseline and CLRD-related mortality during follow-up was defined using the 10th Revision of the International Classification of Diseases (ICD-10). Cox pro

SUBMITTER: Mendy A 

PROVIDER: S-EPMC6579707 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature