Advanced pancreatic cancer clinical trials: The continued underrepresentation of older patients.

ABSTRACT:

Objectives

Older patients make up the majority of patients with pancreatic cancer, with a median age of 71 years at diagnosis. However, older patients are underrepresented in clinical trials in pancreatic cancer. This study investigates trends in age distribution of patients enrolled in clinical trials for advanced pancreatic cancer over time, and examines outcomes and toxicity in older patient subgroups from two studies conducted by Eastern Cooperative Oncology Group and American College of Radiology Imaging Network (ECOG-ACRIN) in this disease.

Materials and methods

16,042 patients from 38 phase III clinical trials for locally advanced or metastatic pancreatic adenocarcinoma published between 1997 and 2016 were identified and included in this analysis. Outcomes and toxicit

SUBMITTER: White MN 

PROVIDER: S-EPMC6579713 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature