Genome-Wide Association Study of Susceptibility Loci for Radiation-Induced Brain Injury.

ABSTRACT:

Background

Radiation-induced brain injury is a nonnegligible issue in the management of cancer patients treated by partial or whole brain irradiation. In particular, temporal lobe injury (TLI), a deleterious late complication in nasopharyngeal carcinoma, greatly affects the long-term life quality of these patients. Although genome-wide association studies (GWASs) have successfully identified single nucleotide polymorphisms (SNPs) associated with radiation toxicity, genetic variants contributing to the radiation-induced brain injury have not yet been assessed.

Methods

We recruited and performed follow-up for a prospective observational cohort, Genetic Architecture of Radiotherapy Toxicity and Prognosis, using magnetic resonance imaging for TLI diagnosis. We conducted genome-w

SUBMITTER: Wang TM 

PROVIDER: S-EPMC6579742 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature