Variability of urinary pesticide metabolite concentrations during pregnancy in the MARBLES Study.

ABSTRACT:

Background

Variability of short-lived urinary pesticide metabolites during pregnancy raises challenges for exposure assessment.

Objectives

For urinary metabolite concentrations 3-phenoxybenzoic acid (3-PBA) and 3,5,6-trichloro-2-pyridinol (TCPy), we assessed: (1) temporal variability; (2) variation of two urine specimens within a trimester; (3) reliability for pesticide concentrations from a single urine specimen to classify participants into exposure tertiles; and (4) seasonal or year variations.

Methods

Pregnant mothers (N = 166) in the MARBLES (Markers of Autism Risk in Babies-Learning Early Signs) Study provided urine specimens (n = 528). First morning void (FMV), pooled, and 24-h specimens were analyzed for 3-PBA and TCPy. For 9 mothers (n = 88 specimens), each u

SUBMITTER: Barkoski J 

PROVIDER: S-EPMC6579749 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature