MiR-665 expression predicts poor survival and promotes tumor metastasis by targeting NR4A3 in breast cancer.

ABSTRACT: Cancer metastasis is the main cause of death in breast cancer (BC) patients. Therefore, prediction and treatment of metastasis is critical for enhancing the survival of BC patients. In this study, we aimed to identify biomarkers that can predict metastasis of BC and elucidate the underlying mechanism of the functional involvement of such markers in metastasis. miRNA expression profile was analyzed using a custom microarray system in 422 BC tissues. The relationship between the upregulated miR-665, metastasis and survival of BC was analyzed and verified in another set of 161 BC samples. The biological function of miR-665 in BC carcinogenesis was explored with in vitro and in vivo methods. The target gene of miR-665 and its signaling cascade were also analyzed. There are 399 differentially e

SUBMITTER: Zhao XG 

PROVIDER: S-EPMC6579763 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature