MiR‑10b‑3p, miR‑8112 and let‑7j as potential biomarkers for autoimmune inner ear diseases.

ABSTRACT: Circulating microRNAs (miRNAs) have been suggested as non‑invasive biomarkers for the diagnosis of several autoimmune diseases. However, to the best of our knowledge, no studies have yet examined the miRNA expression profiles in autoimmune inner ear disease (AIED). The present study aimed to use an miRNA sequencing assay to detect the miRNA expression profiles of serum samples from 3 control mice and 3 antigen‑induced AIED model mice. Differentially expressed miRNAs (DE‑miRNAs) were screened using a t‑test. miRNA target prediction was performed using TargetScan Mouse. Then, the miRNA‑target gene interaction network was constructed and visualized using Cytoscape software. The underlying functions of the target genes of the DE‑miRNAs were predicted using the clusterProfiler package. As a res

SUBMITTER: Zhang J 

PROVIDER: S-EPMC6579970 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature