Association between potentially functional polymorphisms of chemokine family members and the survival of esophageal cancer patients in a Chinese population.

ABSTRACT: Background: The chemokine family plays an important role in the growth, invasion, and metastasis of tumors. However, most studies have only focused on a few genes or a few gene loci, and thus could not reveal the associations between functional polymorphisms of chemokine family members and tumor progression. This study aimed to determine the associations between single nucleotide polymorphisms (SNPs) of chemokine family members and the prognosis of esophageal cancer (EC). Methods: The Cox risk proportional model and log-rank test were used to analyze the associations of 16 potentially functional SNPs in 13 genes from the chemokine family with the survival of 729 Chinese patients with EC. Results: Prognostic analysis on the 16 SNPs showed that different genotypes of 5 S

SUBMITTER: Du JL 

PROVIDER: S-EPMC6580125 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature