Lifespan Changes in Network Structure and Network Topology Dynamics During Rest and Auditory Oddball Performance.

ABSTRACT: Behavioral and physiological evidence suggests that developmental changes lead to enhanced cortical differentiation and integration through maturation and learning, and that senescent changes during aging result in dedifferentiation and reduced cortical specialization of neural cell assemblies. We used electroencephalographic (EEG) recordings to evaluate network structure and network topology dynamics during rest with eyes closed and open, and during auditory oddball task across the lifespan. For this evaluation, we constructed a hyper-frequency network (HFN) based on within- and cross-frequency coupling (WFC and CFC, respectively) at 10 oscillation frequencies ranging between 2 and 20 Hz. We found that WFC increased monotonously across the lifespan, whereas CFC showed a U-shaped relations

SUBMITTER: Muller V 

PROVIDER: S-EPMC6580332 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature