Evolution of NCoR-1 and NCoR-2 corepressor alternative mRNA splicing in placental mammals.

ABSTRACT:

Objective

The NCoR-1 and NCoR-2 corepressors are products of an early gene duplication near the beginning of vertebrate evolution and play both overlapping and divergent roles in development and physiology. Alternative-splicing of NCoR-1 and NCoR-2 further customizes their functions. To better understand the evolutionary basis of this phenomenon we extended our prior study of NCoR-1 and NCoR-2 alternative-splicing to an expanded series of species.

Results

Alternative-splicing of NCoR-2 was observed in all vertebrates examined whereas alternative-splicing of NCoR-1 was largely limited to placental mammals. Notably the most prominent of the NCoR-1 alternative-splicing events specific to the placental lineage, in exon 37 that plays a key role in murine metabolism, mimics in man

SUBMITTER: Privalsky ML 

PROVIDER: S-EPMC6580476 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature