Aneuvis: web-based exploration of numerical chromosomal variation in single cells.

ABSTRACT:

Background

Numerical chromosomal variation is a hallmark of populations of malignant cells. Identifying the factors that promote numerical chromosomal variation is important for understanding mechanisms of carcinogenesis. However, the ability to quantify and visualize differences in chromosome number between experimentally-defined groups (e.g. control vs treated) obtained from single-cell experiments is currently limited by the lack of user-friendly software.

Results

Aneuvis is a web application that allows users to determine whether numerical chromosomal variation exists between experimental treatment groups. The web interface allows users to upload molecular cytogenetic or processed single cell whole-genome sequencing data in a cell-by-chromosome matrix format and automati

SUBMITTER: Pique DG 

PROVIDER: S-EPMC6580570 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature