Insights into Klebsiella pneumoniae type VI secretion system transcriptional regulation.

ABSTRACT:

Background

Klebsiella pneumoniae (KP) is an opportunistic pathogen that mainly causes respiratory and urinary tract infections. The frequent occurrence of simultaneously virulent and multiple drug-resistant isolates led WHO to include this species in the list of top priorities for research and development of therapeutic alternatives. The comprehensive knowledge of the molecular mechanisms underlying KP virulence may lead to the proposal of more efficient and specific drugs. One of its virulence factors is the Type VI Secretion System (T6SS), which contributes to bacterial competition, cell invasion and in vivo colonisation. Despite the few studies showing the involvement of T6SS in KP pathogenesis, little is known concerning the regulation of its expression. The understanding of re

SUBMITTER: Barbosa VAA 

PROVIDER: S-EPMC6580597 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature