Reducing injection intensity is associated with decreased risk for invasive bacterial infection among high-frequency injection drug users.

ABSTRACT:

Background

Bacterial infection is a major cause of morbidity and mortality for persons who inject drugs (PWID). Injection cessation may help abrogate such infections, but maintaining complete cessation is challenging. Limited data exists on the role of reduced injection intensity on invasive bacterial infection risk. We sought to evaluate decreased risk for bacterial infections following cessation and substantive reduction in the injection intensity.

Methods

Participants were persons in the AIDS Linked to the Intravenous Experience (ALIVE) cohort with initial high-frequency injection drug use (> 1 daily). Pooled logistic regression with generalized estimating equations was used to estimate risk for invasive bacterial infection (pneumonia, endocarditis, or sepsis) among parti

SUBMITTER: Islam S 

PROVIDER: S-EPMC6580632 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature