Out-of-hospital initiation of hypothermia in ST-segment elevation myocardial infarction: a randomised trial.

ABSTRACT:

Objective

To evaluate the effect of prereperfusion hypothermia initiated in the out-of-hospital setting in awake patients with ST-segment elevation myocardial infarction (STEMI) on myocardial salvage measured by cardiac MRI (CMR).

Methods

Hypothermia was initiated within 6 hours of symptom onset by the emergency medical service with surface cooling pads and cold saline, and continued in the cath lab with endovascular cooling (target temperature: ≤35°C at time of reperfusion). Myocardial salvage index (using CMR) was compared in a randomised, controlled, open-label, endpoint blinded trial to a not-cooled group of patients at day 4±2 after the event.

Results

After postrandomisation exclusion of 19 patients a total of 101 patients were included in the intention-to-treat

SUBMITTER: Testori C 

PROVIDER: S-EPMC6580740 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature