Gut microbiome analysis as a tool towards targeted non-invasive biomarkers for early hepatocellular carcinoma.

ABSTRACT:

Objective

To characterise gut microbiome in patients with hepatocellular carcinoma (HCC) and evaluate the potential of microbiome as non-invasive biomarkers for HCC.

Design

We collected 486 faecal samples from East China, Central China and Northwest China prospectively and finally 419 samples completed Miseq sequencing. We characterised gut microbiome, identified microbial markers and constructed HCC classifier in 75 early HCC, 40 cirrhosis and 75 healthy controls. We validated the results in 56 controls, 30 early HCC and 45 advanced HCC. We further verified diagnosis potential in 18 HCC from Xinjiang and 80 HCC from Zhengzhou.

Results

Faecal microbial diversity was increased from cirrhosis to early HCC with cirrhosis. Phylum Actinobacteria was increased in ear

SUBMITTER: Ren Z 

PROVIDER: S-EPMC6580753 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature