Dendrigraft of Poly-l-lysine as a Promising Candidate To Reverse Heparin-based Anticoagulants in Clinical Settings.
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ABSTRACT:
SUBMITTER: Ourri B
PROVIDER: S-EPMC6580796 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
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Dendrigraft of Poly-l-lysine as a Promising Candidate To Reverse Heparin-based Anticoagulants in Clinical Settings.
Ourri Benjamin B Francoia Jean-Patrick JP Monard Gerald G Gris Jean-Christophe JC Leclaire Julien J Vial Laurent L
ACS medicinal chemistry letters 20190508 6
By using a combination of experimental and computational experiments, we demonstrated that a second-generation dendrigraft of poly-l-lysine neutralizes the anticoagulant activity of unfractionated heparin, low-molecular-weight heparin, and fondaparinux more efficiently than protamine does in human plasma, making this synthetic polymer a promising surrogate of this problematic protein in clinical settings. ...[more]
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