WRN helicase is a synthetic lethal target in microsatellite unstable cancers.

ABSTRACT: Synthetic lethality-an interaction between two genetic events through which the co-occurrence of these two genetic events leads to cell death, but each event alone does not-can be exploited for cancer therapeutics¹. DNA repair processes represent attractive synthetic lethal targets, because many cancers exhibit an impairment of a DNA repair pathway, which can lead to dependence on specific repair proteins². The success of poly(ADP-ribose) polymerase 1 (PARP-1) inhibitors in cancers with deficiencies in homologous recombination highlights the potential of this approach³. Hypothesizing that other DNA repair defects would give rise to synthetic lethal relationships, we queried dependencies in cancers with microsatellite instability (MSI), which results from de

SUBMITTER: Chan EM 

PROVIDER: S-EPMC6580861 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature