Inflammatory myopathy associated with anti-mitochondrial antibodies: A distinct phenotype with cardiac involvement.

ABSTRACT:

Objective

In the context of clinical evaluations performed on our prospective myositis cohort, we noted a striking association of severe cardiac disease in myositis patients with anti-mitochondrial antibodies. We sought to review all cases of anti-mitochondrial antibody (AMA) associated myositis in our cohort to describe the clinical features of this disease subset.

Methods

We identified 7 patients with confirmed anti-mitochondrial antibodies who presented as an inflammatory myopathy. A retrospective chart review was completed to assess their clinical presentation, laboratory, imaging, electrophysiologic, and histopathologic features.

Results

One patient presented with dermatomyositis and 6 were classified as polymyositis using Bohan and Peter criteria. In all but one

SUBMITTER: Albayda J 

PROVIDER: S-EPMC6581062 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature