Associations and Heritability of Auditory Encoding, Gray Matter, and Attention in Schizophrenia.

ABSTRACT:

Background

Auditory encoding abnormalities, gray-matter loss, and cognitive deficits are all candidate schizophrenia (SZ) endophenotypes. This study evaluated associations between and heritability of auditory network attributes (function and structure) and attention in healthy controls (HC), SZ patients, and unaffected relatives (UR).

Methods

Whole-brain maps of M100 auditory activity from magnetoencephalography recordings, cortical thickness (CT), and a measure of attention were obtained from 70 HC, 69 SZ patients, and 35 UR. Heritability estimates (h2r) were obtained for M100, CT at each group-difference region, and the attention measure.

Results

SZ patients had weaker bilateral superior temporal gyrus (STG) M100 responses than HC and a weaker right frontal M100 res

SUBMITTER: Chen YH 

PROVIDER: S-EPMC6581123 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature