Salience-Default Mode Functional Network Connectivity Linked to Positive and Negative Symptoms of Schizophrenia.

ABSTRACT: Schizophrenia is a complex, debilitating mental disorder characterized by wide-ranging symptoms including delusions, hallucinations (so-called positive symptoms), and impaired motor and speech/language production (so-called negative symptoms). Salience-monitoring theorists propose that abnormal functional communication between the salience network (SN) and default mode network (DMN) begets positive and negative symptoms of schizophrenia, yet prior studies have predominately reported links between disrupted SN/DMN functional communication and positive symptoms. It remains unclear whether disrupted SN/DMN functional communication explains (1) solely positive symptoms or (2) both positive and negative symptoms of schizophrenia. To address this question, we incorporate time-lag-shifted functio

SUBMITTER: Hare SM 

PROVIDER: S-EPMC6581131 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature