Quantitative assessment of the activity of antituberculosis drugs and regimens.

ABSTRACT: Introduction: Identification of optimal drug doses and drug combinations is crucial for optimized treatment of tuberculosis. Areas covered: An unprecedented level of research activity involving multiple approaches is seeking to improve tuberculosis treatment. This report is a review of the quantitative methods currently used on clinical data sets to identify drug exposure targets and optimal drug combinations for tuberculosis treatment. A high-level summary of the methods, including the strengths and weaknesses of each method and potential methodological improvements is presented. Methods incorporating data generated from multiple sources such as in vitro and clinical studies, and their potential to provide better estimates of pharmacokinetic/pharmacodynamic (PK/PD) ta

SUBMITTER: Chirehwa MT 

PROVIDER: S-EPMC6581212 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature