Discovery of ¹⁸F-JK-PSMA-7, a PET Probe for the Detection of Small PSMA-Positive Lesions.

ABSTRACT: Prostate-specific membrane antigen (PSMA), expressed by most prostate carcinomas (PCa), is a promising target for PCa imaging. The application of PSMA-specific ¹⁸F-labeled PET probes such as ¹⁸F-DCFPyL and ¹⁸F-PSMA-1007 considerably improved the accuracy of PCa tumor detection. However, there remains a need for further improvements in sensitivity and specificity. The aim of this study was the development of highly selective and specific PSMA probes with enhanced imaging properties, in comparison with ¹⁸F-DCFPyL, ¹⁸F-PSMA-1007, and ⁶⁸Ga-PSMA-11. Methods: Eight novel ¹⁸F-labeled PSMA ligands were prepared. Their cellular uptake in PSMA-positive LNCaP C4-2 and PSMA-negative PC-3 cells was compared with that of

SUBMITTER: Zlatopolskiy BD 

PROVIDER: S-EPMC6581226 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature