Metabolic Subtyping of Pheochromocytoma and Paraganglioma by ¹⁸F-FDG Pharmacokinetics Using Dynamic PET/CT Scanning.

ABSTRACT: Static single-time-frame ¹⁸F-FDG PET/CT is useful for the localization and functional characterization of pheochromocytomas and paragangliomas (PPGLs). ¹⁸F-FDG uptake varies between PPGLs with different genotypes, and the highest SUVs are observed in cases of succinate dehydrogenase (SDH) mutations, possibly related to enhanced aerobic glycolysis in tumor cells. The exact determinants of ¹⁸F-FDG accumulation in PPGLs are unknown. We performed dynamic PET/CT scanning to assess whether in vivo ¹⁸F-FDG pharmacokinetics has added value over static PET to distinguish different genotypes. Methods: Dynamic ¹⁸F-FDG PET/CT was performed on 13 sporadic PPGLs and 13 PPGLs from 11 patients with mutations in SDH complex subunit

SUBMITTER: van Berkel A 

PROVIDER: S-EPMC6581230 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature