Association of maternal circulating 25(OH)D and calcium with birth weight: A mendelian randomisation analysis.

ABSTRACT:

Background

Systematic reviews of randomised controlled trials (RCTs) have suggested that maternal vitamin D (25[OH]D) and calcium supplementation increase birth weight. However, limitations of many trials were highlighted in the reviews. Our aim was to combine genetic and RCT data to estimate causal effects of these two maternal traits on offspring birth weight.

Methods and findings

We performed two-sample mendelian randomisation (MR) using genetic instrumental variables associated with 25(OH)D and calcium that had been identified in genome-wide association studies (GWAS; sample 1; N = 122,123 for 25[OH]D and N = 61,275 for calcium). Associations between these maternal genetic variants and offspring birth weight were calculated in the UK Biobank (UKB) (sample 2; N = 190,406)

SUBMITTER: Thompson WD 

PROVIDER: S-EPMC6581250 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature