MR fingerprinting with simultaneous T1, T2, and fat signal fraction estimation with integrated B0 correction reduces bias in water T1 and T2 estimates.

ABSTRACT: PURPOSE:MR fingerprinting (MRF) sequences permit efficient T1 and T2 estimation in cranial and extracranial regions, but these areas may include substantial fat signals that bias T1 and T2 estimates. MRI fat signal fraction estimation is also a topic of active research in itself, but may be complicated by B0 heterogeneity and blurring during spiral k-space acquisitions, which are commonly used for MRF. An MRF method is proposed that separates fat and water signals, estimates water T1 and T2, and accounts for B0 effects with spiral blurring correction, in a single sequence. THEORY AND METHODS:A k-space-based fat-water separation method is further extended to unbalanced steady-state free precession MRF with swept echo time. Repeated application of this k-space fat-water separation to demodul

SUBMITTER: Ostenson J 

PROVIDER: S-EPMC6581466 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature