Subthalamic deep brain stimulation sweet spots and hyperdirect cortical connectivity in Parkinson's disease.

ABSTRACT:

Objectives

Firstly, to identify subthalamic region stimulation clusters that predict maximum improvement in rigidity, bradykinesia and tremor, or emergence of side-effects; and secondly, to map-out the cortical fingerprint, mediated by the hyperdirect pathways which predict maximum efficacy.

Methods

High angular resolution diffusion imaging in twenty patients with advanced Parkinson's disease was acquired prior to bilateral subthalamic nucleus deep brain stimulation. All contacts were screened one-year from surgery for efficacy and side-effects at different amplitudes. Voxel-based statistical analysis of volumes of tissue activated models was used to identify significant treatment clusters. Probabilistic tractography was employed to identify cortical connectivity patterns as

SUBMITTER: Akram H 

PROVIDER: S-EPMC6581538 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature