Posttreatment Effect of MGMT Methylation Level on Glioblastoma Survival.

ABSTRACT: The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) removes temozolomide-induced alkylation, thereby preventing DNA damage and cytotoxicity. We investigated the prognostic effect of different MGMT methylation levels on overall and progression-free survival in 327 patients with primary glioblastoma undergoing standard treatment. We obtained MGMT methylation level in 4 CpG sites using pyrosequencing. The association between MGMT methylation level and survival was investigated using Cox proportional hazards model and an extension to detect time-varying effects. We found an association between MGMT methylation level and overall survival (OS) from around 9 months after the diagnosis, with no association between MGMT methylation level and OS before that. For patients surviving a

SUBMITTER: Dahlrot RH 

PROVIDER: S-EPMC6581556 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature