Multilocus sequence typing of Cryptococcus neoformans var. grubii from Laos in a regional and global context.

ABSTRACT: Cryptococcosis causes approximately 180 000 deaths each year in patients with human immunodeficiency virus (HIV). Patients with other forms of immunosuppression are also at risk, and disease is increasingly recognized in apparently immunocompetent individuals. Cryptococcus neoformans var. grubii, responsible for the majority of cases, is distributed globally. We used the consensus ISHAM Multilocus sequence typing (MLST) scheme to define the population structure of clinical C. neoformans var. grubii isolates from Laos (n = 81), which we placed into the global context using published MLST data from other countries (total N = 1047), including a reanalysis of 136 Vietnamese isolates previously reported. We observed a phylogeographical relationship in which the Laotian population was similar to

SUBMITTER: Thanh LT 

PROVIDER: S-EPMC6581559 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature