Characterization of MRI techniques to assess neonatal brain oxygenation and blood flow.

ABSTRACT: There is increasing interest in applying physiological MRI in neonates, based on the premise that physiological parameters may provide an early biomarker of neonatal brain health and injury. Two commonly used techniques are oxygen extraction fraction (OEF) measurement using T₂ -relaxation-under-spin-tagging (TRUST) MRI and cerebral blood flow measurement using phase-contrast (PC) quantitative flow MRI, which collectively provide an assessment of the brain's oxygen consumption. However, prior research has only demonstrated proof of principle of these methods in neonates, without characterization or benchmarking of the techniques. This is because available time is limited in neonatal subjects, especially when scans are performed as add-ons to clinical scans (typically less than 5 

SUBMITTER: Liu P 

PROVIDER: S-EPMC6581605 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature