Autonomic neurophysiologic implications of disorders comorbid with bladder pain syndrome vs myofascial pelvic pain.

ABSTRACT:

Aims

The neuropathophysiology of a debilitating chronic urologic pain condition, bladder pain syndrome (BPS), remains unknown. Our recent data suggests withdrawal of cardiovagal modulation in subjects with BPS, in contrast to sympathetic nervous system dysfunction in another chronic pelvic pain syndrome, myofascial pelvic pain (MPP). We evaluated whether comorbid disorders differentially associated with BPS vs MPP shed additional light on these autonomic differences.

Methods

We compared the presence and relative time of onset of 27 other medical conditions in women with BPS, MPP, both syndromes, and healthy subjects. Analysis included an adjustment for multiple comparisons.

Results

Among 107 female subjects (BPS alone = 32; BPS with MPP = 36; MPP alone = 9; healthy co

SUBMITTER: Chelimsky GG 

PROVIDER: S-EPMC6581610 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature