Sex-based differences in transfusion need after severe injury: Findings of the PROPPR study.

ABSTRACT:

Background

Women are underrepresented in trauma research, and aggregated results of clinical trials may mask effects that differ by sex. It is unclear whether women respond differently to severe hemorrhage compared with men. We sought to evaluate sex-based differences in outcomes after severe trauma with hemorrhage.

Methods

We performed a secondary analysis of the Pragmatic Randomized Optimal Platelet and Plasma Ratios trial. Trauma patients predicted to require massive transfusion were randomized to a 1:1:1 vs 1:1:2 plasma to platelet to red blood cell transfusion ratio. Analysis was performed according to sex, controlling for clinical characteristics and transfusion arm.

Results

A total of 134 women and 546 men were analyzed. In multivariable analysis, there was no

SUBMITTER: McCrum ML 

PROVIDER: S-EPMC6581613 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature