Hepatovirus 3ABC proteases and evolution of mitochondrial antiviral signaling protein (MAVS).

ABSTRACT:

Background & aims

Unlike other hepatitis viruses that have infected primates for millions of years, hepatitis A virus (HAV) likely entered human populations only 10-12 thousand years ago after jumping from a rodent host. The phylogeny of modern hepatoviruses that infect rodents and bats suggest that multiple similar host shifts have occurred in the past. The factors determining such shifts are unknown, but the capacity to overcome innate antiviral responses in a foreign species is likely key.

Methods

We assessed the capacity of diverse hepatovirus 3ABC proteases to cleave mitochondrial antiviral signaling protein (MAVS) and disrupt antiviral signaling in HEK293 and human hepatocyte-derived cell lines. We also applied maximum-likelihood and Bayesian algorithms to identify sit

SUBMITTER: Feng H 

PROVIDER: S-EPMC6581616 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature