A Distinct Role of the Autonomic Nervous System in Modulating the Function of Lymphatic Vessels under Physiological and Tumor-Draining Conditions.

ABSTRACT: Lymphatic vessels (LVs) are important in the regulation of tissue fluid homeostasis and the pathogenesis of tumor progression. We investigated the innervation of LVs and the response to agonists and antagonists of the autonomic nervous system in vivo. While skin-draining collecting LVs express muscarinic, α₁- and β₂-adrenergic receptors on lymphatic endothelial cells and smooth muscle cells, intestinal lacteals express only β-adrenergic receptors and muscarinic receptors on their smooth muscle cells. Quantitative in vivo near-infrared imaging of the exposed flank-collecting LV revealed that muscarinic and α₁-adrenergic agonists increased LV contractility, whereas activation of β₂-adrenergic receptors inhibited contractility and initiated nitric o

SUBMITTER: Bachmann SB 

PROVIDER: S-EPMC6581737 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature