Evidence of Recent Genomic Evolution in Gonococcal Strains With Decreased Susceptibility to Cephalosporins or Azithromycin in the United States, 2014-2016.

ABSTRACT:

Background

Given the lack of new antimicrobials or a vaccine, understanding the evolutionary dynamics of Neisseria gonorrhoeae is a significant public and global health priority. We investigated the emergence and spread of gonococcal strains with decreased susceptibility to cephalosporins and azithromycin using detailed genomic analyses of gonococcal isolates collected in the United States, 2014-2016.

Methods

We sequenced genomes of 649 isolates collected through the Gonococcal Isolate Surveillance Project. We examined the genetic relatedness of isolates and assessed associations between clades and various genotypic and phenotypic combinations.

Results

We identified a large and clonal lineage of strains (MLST ST9363) associated with elevated azithromycin minimum inhib

SUBMITTER: Thomas JC 

PROVIDER: S-EPMC6581898 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature