Cervical Cytokines Associated With Chlamydia trachomatis Susceptibility and Protection.

ABSTRACT:

Background

Chlamydia trachomatis can cause reproductive morbidities after ascending to the upper genital tract of women, and repeated infection can lead to worse disease. Data related to protective immune responses at the cervical mucosa that could limit chlamydial infection to the cervix and/or prevent reinfection inform vaccine approaches and biomarkers of risk.

Methods

We measured 48 cytokines in cervical secretions from women having chlamydial cervical infection alone (n = 92) or both cervical and endometrial infection (n = 68). Univariable regression identified cytokines associated with differential odds of endometrial infection and reinfection risk, and multivariable stepwise regression identified cytokine ratios associated with differential risk.

Results

Elevat

SUBMITTER: Poston TB 

PROVIDER: S-EPMC6581900 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature