In vivo studies demonstrate that endothelin-1 traps are a potential therapy for type I diabetes.

ABSTRACT:

Background

Type 1 diabetes is a serious, lifelong condition where the body's blood glucose level increases because of the body's inability to make insulin. An important consequence of this is the increased expression of extracellular matrix proteins, such as fibronectin and collagen 4α1, in key tissues and organs like the heart and kidneys. Diabetes is also associated with increased plasma levels of the vasoactive peptide endothelin (ET)-1. This further aggravates the expression of the ECM proteins. There are also important consequences of increased glucose and ET-1 levels in diabetes on the heart, termed diabetic cardiomyopathy.

Methods

We have previously reported the development of ET-traps, which potently and significantly reduce pathological levels of ET-1. In this study

SUBMITTER: Jain A 

PROVIDER: S-EPMC6582002 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature